Specific entropy9/6/2023 ![]() ![]() As energy, in any form is supplied to a system, its molecules begin to rotate, vibrate and translate, which is observable as a rise in temperature. In classical terms, systems at absolute zero have no energy and the atoms or molecules would be close packed together. The first law deals with the conservation of energy, the second law is concerned with the direction in which spontaneous reactions go, and the third law establishes that at absolute zero, all pure substances have the same entropy, which is taken, by convention, to be zero. ![]() Alongside this it is important to bear in mind the three laws of thermodynamics. ![]() We prefer to consider that the entropy of a system corresponds to the molecular distribution of its molecular energy among the available energy levels and that systems tends to adopt the broadest possible distribution. Secondly, the equation ( ii) defining entropy change does not recognise that the system has to be at equilibrium for it to be valid. First the units of entropy are Joules per Kelvin but the degree of disorder has no units. This more modern approach has two disadvantages. However, it is more common today to find entropy explained in terms of the degree of disorder in the system and to define the entropy change, Δ S, as: Where Q is the quantity of heat and T the thermodynamic temperature. Many earlier textbooks took the approach of defining a change in entropy, Δ S, via the equation: Generations of students struggled with Carnot's cycle and various types of expansion of ideal and real gases, and never really understood why they were doing so. The concept of entropy emerged from the mid-19th century discussion of the efficiency of heat engines. Entropy is a thermodynamic property, like temperature, pressure and volume but, unlike them, it can not easily be visualised. Thermodynamic properties depend on the current state of the system but not on its previous history and are either extensive - their values depend on the amount of substance comprising the system, eg volume - or intensive - their values are independent of the amount of substance making up the system, eg temperature and pressure. Thermodynamics deals with the relation between that small part of the universe in which we are interested - the system - and the rest of the universe - the surroundings. Entropy is dynamic - something which static scenes don't reflect ![]()
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Iguard apple9/6/2023 ![]() When you can easily and conveniently assign different access rights to your employees, you can plan your security better and maximize the effectiveness of your resources. And depending on the different time period, you can set up the iGuard that the users can just simply presents his smartcard to get authorized (such as during high-traffic period), or require the high-security fingerprint verification (such as after office hours or during weekends and holidays). With iGuard, users can be authenticated and verified through combinations of Fingerprint, Smart-card or Password. Can access individual devices from the corporate LAN or the public Internet.Gather necessary data remotely at the central office from various remote locations.Allows you to keep track of employee attendance and time attendance records, irrespective of geographic location.TCP/IP allows for multiple location coverage and world-wide access.Simple access and download procedures via any standard web browser on any Internet enabled device (even the new Apple iPad or any smart phone). ![]() A 24/7 time management solution that is easy to use and manage.The genius of the iGuard system is its simplicity. ![]() ASG Global () is one of the oldest and most prolific distributors of the iGuard platform having multiple installations on six continents (sorry Antarctica - not there yet.). This was one of the requirements for ASG Global becoming involved with the iGuard platform in 2002. The system is stable and is not constantly being upgraded/changed/modified or messed with. This is one of the many selling features of the iGuard system. There have been many changes over the years both internally and externally as new technologies are added or upgraded, but the core of the iGuard system remains stable. NGO's, medium and small businesses alike since 1999. ![]() IGuard has been continuously used around the world by many customers including fortune 100 corporations, governments. New Apple® iPad or iPhone or Android Tablets & Phones (No APP is required) The iGuard is designed to beĬompatible with all modern browsers and can even be managed using the Incorporates an embedded Web Server, which enables all computers, suchĪs Apple Mac OSX, Windows PCs, Linux PCs, Network Appliances, Smart Phones, Tablets or any Servers in the corporateĬomputer network to setup, maintain and access the information using Multi-factor authentication, the iGuard system provides unparalleled The iGuard Security System is a field-proven Biometrics, and/orĬontactless Smart Card Access Control & Time Attendance NetworkĪppliance utilizing fingerprint verification coupled with smart ![]() 89 clearview drive brookfield ct9/6/2023 ![]() ![]() This is a must see home, schedule a showing today. 43 CLEARVIEW DR BROOKFIELD, CT 06804: Sale Price: 0: Certificate: Book & Page : 778/ 195: Sale Date: : Ownership History. Enjoy Candlewood Lake at its best, great location in Brookfield close to shopping, restaurants, Cadigan Town Park and main highway. Mblu A07/ / 212/ / Acct 04166000 Owner RICHARD POCHETTI TTEE OF Assessment 269,940 Appraisal 385,620. The natural wood shake exterior is reminiscent of the eastern shore vacation spots of New England! Candlewood Shores offers fabulous amenities from the light sandy beach, volleyball & basketball courts, playground to a boat mooring wait list for an active & fun lifestyle. Winslow - 1600 North Park Drive - North Park Plaza - Store 3429, (Opened on November 16, 1989). This property is currently available for sale and was listed by Smart MLS on May 9, 2023. Well maintained mechanicals and newer hot water heater. 71 Clearview Dr, Brookfield, CT 06804 is a lot/land. ![]() Large basement area stores your kayaks, water sport equipment and hammock in the off season along with a nice workshop & tool storage area. storage galore in this home including a cedar lined closet! The foyer room with picturesque windows lets the light in, a wonderful home for your indoor plants and exotic trees. Ample wood cabinetry and nice appliances complete the eat-in kitchen and offers additional pantry. 89 Clearview Dr is a home located in Fairfield County with nearby schools including Huckleberry Hill Elementary School and Whisconier Middle School. Ensuite primary bedroom is adjacent to one of the three extensive decks complete with firepit, overlooking the private grassy yard surrounded by evergreens. 1Bath 1,296Sq Ft 9,583Sf Lot About This Home This home is located at 89 Clearview Dr, Brookfield, CT 06804 and has been listed on since 18 June 2021. ![]() This affordable Home is located in the the Candlewood Lake Comm. Captivating long views & sunsets of Candlewood Lake will be enjoyed all year round from almost every room in this very well-maintained adorable ranch! Gorgeous wood burning, stone fireplace focal point and vaulted ceilings with skylight grace the spacious living room. house located at 89 Kellogg St, Brookfield, CT 06804 sold for 260,000 on Apr 30, 2019. View details, map and photos of this single family property with 4 bedrooms and 3 total baths. CLARENCE CENTER 902 WILLOW GOT 902 WILLOW LAKE CT VALLEY STREAM RD. Sold - 13 Clearview Dr, Brookfield, CT - 395,000. Candlewood Shores Don't miss this opportunity to be on. CANDLEWOOD SHORES! Here is your opportunity to enjoy life in this exceptional lake community of Brookfield. HELENWOOD GENTWOOD CLEARVIEW GLENWOOD BRENTWOOD NORWOOD HIRSH WOOD ERICSON WESTWOOD. house located at 89 Clearview Dr, Brookfield, CT 06804 sold for 320,000 on Oct 29, 2021. ![]() ![]() I'm retraining out of 1A8 into the 1N at Goodfellow right now and it sucks. I don't believe you can become a linguist without getting 100 or better on DLAB unless they've totally changed something. Your mileage may vary I hear things are different elsewhere. Other stuff: pay is better, $250-$400 per month in language pay, $125+ per month in flight pay, deployments of course come with additional pay and no taxes. Generally chill environment, do some work, have some "root beer" and jalapeno popcorn, leave at 3 or so independent self-starters will find more success than people who prefer a more structured environment. As aircrew you have, rough estimate, 50 or so ground and flight training items that it's your responsibility to be current in, so that occupies some time as well. I rode around in helicopters and rucked around in the desert for a week playing OPFOR for a major exercise. Many opportunities to do fun bonus stuff - RED FLAG Nellis or Alaska, ANGEL THUNDER, FOAL EAGLE/TEAM SPIRIT/whatever it's called now, joint stuff with other services, etc. Training sorties are boring, but at least it breaks the monotony. Office work is office work and depends on the office, generally pretty low-key though. Basically eat -> fly -> gym -> eat -> chill -> sleep, lather, rinse, repeat, count your fat stacks of Benjamins.Īverage work week: on average, office work 4 days, fly 1 day. Deployments are cool and people volunteer for them all the time. Could be anything from 1:1 dwell to essentially voluntary. I spoke a little bit of Italian, which I've since forgotten.ĭeployments: depends on airframe. Goodfellow sucks, unless you have no taste, in which case you'll love San Angelo. As a prior service retrainee you'll be loving it though, all the benefits of being in Monterey without the AETC BS. Since everyone else seems to be a cave-dweller, here's an aircrew perspective. Troll and spam posts/comments will be deleted.Īll Airmen from any Air Force are welcome here, though we are overwhelmingly from the US! No making fun of people based on their appearance or personal attacks. Other photos of people in uniform should have their face and name tape obscured in some way. Photos of people in uniform should be a public figure, or related to a news article or current event. Violators are subject to the UCMJ, Article 93 (Cruelty and Maltreatment towards others). R/AirForce and the Air Force in general is a hooah free zone. No personal attacks.Įncouraging or suggesting suicide, even in a joking way, will result in an instant and permanent ban.įriendly bashing between jobs is ok, as long as it doesn't go too far. If you have questions related in any way to joining the Air Force, whether commissioning or enlisting, ROTC, AF Academy, OTS or BMT, post your questions on /r/AirForceRecruits OPSEC/PII material will result in an instant ban ( see more) ![]() Job Descriptions | Uniform Questions | Common Acronyms Mental Health/Suicide Resources Apply for your Reddit Achievement Ribbon Subreddit Discord Interested in joining the Air Force? Please post on /r/AirForceRecruits ![]() Feel free to discuss anything about the Air Force or military in general. Welcome to the United States Air Force subreddit. ![]() Mac operating systems9/6/2023 ![]() Mac OS 9’s lasting legacy was providing developers with the ability to adopt some features of Mac OS X before its arrival. It improved on earlier support for AirPort wireless networking, brought on-the-fly file encryption to the Mac, and had much better USB drivers than earlier versions. In 1999, Apple released Mac OS 9 as the last classic Mac operating system. Jobs had spearheaded the move to a UNIX-based OS called NeXTSTEP while at NeXT, and when Apple purchased the company, it also brought over the basis for Mac OS X. With Steve Jobs back in charge at Apple, the company began to work in earnest on a replacement for the dated operating systems. Mac OS 9: The last “Classic” Mac operating system Probably the most significant change was to the Mac file system, as Mac OS 8 introduced HFS+, the file system used in macOS up to version 13 “High Sierra” when APFS arrived. True multi-threading appeared, allowing file system operations to happen in the background. Mac OS 8 was quite popular, primarily because Mac users had been hungering for a replacement to System 7. Mac OS 8 Desktop, featuring Microsoft Internet Explorer as the internet browser Jobs had it renamed in order to take advantage of a legal loophole and stop third-party licensing to clone manufacturers. It was originally supposed to be called Mac OS 7.7. Shortly after Steve Jobs returned to Apple from his NeXT adventure, Apple released Mac OS 8. With Mac OS 7.6, Apple dropped the “System” designation as it was trying to drum up support for the Mac operating system on third-party Mac clones. AppleScript is part of today’s Automator and offers a way to automate operating system and app functions.Ībout this time, Apple started using PowerPC processors in the Mac line. It was a big improvement over earlier versions, offering more stability, virtual memory support, cooperative multitasking through MultiFinder, and the AppleScript scripting language. Of all of the original System releases, I remember System 7 as being the most long-lived. ![]() System 6 also brought support for the Motorola 68030 CPU and the 1.44MB SuperDrive floppy. That bootable diskette was a direct ancestor of the Disk Utility we still use today. One of these diskettes, “Disk Utilities 1”, came with Disk First Aid and HD SC Setup. For $49, users got three manuals and four diskettes. System 5 and 6Īpple began charging for operating system upgrades with System 5. ADB also worked with adapters to connect Macs to AppleTalk networks. ![]() It also supported Apple Desktop Bus, used for many years to connect keyboards, mice, and other devices. System 4.1 was notable in that it supported the Motorola 68020 CPU, expansion slots, and color display of the Macintosh II. ![]() ![]() System 3 brought 800K startup drives, SCSI for connectivity to scanners, printers, and storage, AppleShare (early networking and file sharing). For example, System 2 brought multiple folders and screenshots (Command – Shift – 3), while System 2.1 added support for the Apple Hard Disk 20 (that’s 20MB, not GB…). System 1 through System 4 (1987) offered a few enhancements along the way. Overlapping, resizable windows the Finder, folders, a mouse-controlled pointer, the Trash can, and the top menu bar anchored by the Apple icon. In the two years that the Lisa was on the market, it sold only 10,000 units.Īs crude as the System 1 desktop looks in the screenshot above, it introduced many concepts that still exist in macOS today. Apple had released the Lisa with a GUI in 1983, but it was ridiculously expensive ($9,995, equivalent to almost $26,000 in 2020 dollars), slow, and used unreliable floppy disks coupled with a 5 MB hard disk drive. It was the first popular consumer OS to use a graphical user interface. For those of us who were around at the time the first Mac was released, System 1 was a revolutionary operating system. On that day, twenty years ago, Apple introduced the next generation of the Mac operating system – Mac OS X 10.0 “Cheetah.” The introduction was no small matter, as it marked a change in how Macs work that remains up to this day with macOS 11 “Big Sur.” Let’s take a look at the history of Mac operating systems from 1984 until now, starting with the “Classic” operating system introduced in 1984 and ending with Big Sur.Īt the beginning (1984), there was System 1. March 24, 2001, was a banner day for Mac users. ![]() Modern bird feeder pole9/6/2023 ![]() ![]() ![]() All wood products have been replaced with resin ones including two WBU hopper-style feeders, a catch tray that doubles as a platform feeder and a suet feeder for our woodpeckers. If you are looking to set up a bird-feeding station, be sure to check out my post on S etting Up a Bird Feeding Pole.Īt our feeding station, plastic, or more appropriately resin, certainly takes centre stage. The removable screen bottom is treated with EcoClean® Product Protection, providing 24/7 product protection.” … Perch drains allow seed to drop out of the feeder for ground-feeding birds to eat, and angled perches let empty seed hulls be blown away by the wind. EcoTough® feeders are environmentally friendly, high quality products made from recycled plastic milk jugs. They describe their EcoTough Classic hopper-style feeder as a high quality feeder that “won’t crack, fade or rot. Wild Birds Unlimited is a leader in the industry when it comes to backyard bird feeding. Their church-style-bird feeder is currently on clearance and would be a good choice as both a high quality bird feeder and piece of garden art. If you are looking for a stylish addition to your garden, Look no further than Garret Wade’s impressive line of feeders. Wild Birds Unlimited is not the only location where you can purchase high-quality, plastic feeders. I’m sure more are available in-store, but there is no question that the eco-friendly recycled plastic feeders are proving popular despite their high price tag. In fact, a quick look at the Wild Birds Unlimited website shows 12 eco-friendly (resin) hopper bird feeders and only a single wood hopper feeder. A quick wipe with bleach gets the job done and this will not damage the resins. Regular cleaning of the resin feeders is quick and easy. Having plastic or resin bird feeders is no guarantee that your backyard birds will escape the deadly virus, but plastic feeders are easier to keep clean and should help keep the birds at your feeder safe. This eliminates seed build-up and keeps the number of birds at the feeding station down considerably.įor more on purchasing these bird feeders on a budget check out my best bird feeder finds. I have seriously reduced the amount of feed I use this year, preferring to put out just a little of the no-mess blend on a daily basis. What can we do to reduce the spread of Avian Flu? We also always recommend that you follow any recommendations put out by your state government, such as the recent request to take down feeders in Illinois.” We do always recommend that you clean bird feeders and birdbaths regularly as a way to keep many kinds of diseases at bay. It was detected in Ontario in March of this year entering from migrating birds.Īccording to Cornell University’s All About Birds website: There is currently very low risk of an outbreak among wild songbirds, and no official recommendation to take down feeders unless you also keep domestic poultry, according to the National Wildlife Disease Program. It struck earlier this year in parts of the United States with primarily waterfowl and migrated north to northern states and into Canada. This is especially important now with the emergence of Avian flu, which can be devastating to large flocks of birds that come in contact with the virus. The new plastic or resin-based feeders are easier to clean and keep clean and that helps to reduce the spread of disease among our songbirds. I love wood as much as the next guy, but when it comes to bird feeders, today’s more modern resin/plastic bird feeders are always the better choice. The white and black coated finish protects the feeder from elemental wear, and both lids lift for cleaning and refilling.Avian flu outbreak is good reason to move to modern resin-based or plastic feeders The dual perches allow you to see plenty of avian activity, and an attached cord handily showcases the feeder on a bracket or branch. ![]() The springs at each end of the feeder may be adjusted to increase or decrease resistance based upon the birds you wish to feed, and the clear panels make it simple to monitor seed levels. If a squirrel or other larger animal rests on these perches, a metal lid covers the seed ports, preventing the animal from reaching the seed. ![]() of seed, and weight-sensitive perches on both sides allow select birds to dine. A black, metal construction mimics a mailbox, completed by lids on both sides, each resembling the flap of an envelope and with the AIR MAIL imprint inscribed across them. Modern Farmhouse Absolute Squirrel-Resistant Air Mail Feeder - Add a novelty enevlope shaped adornment above your yard or garden with the Absolute Air Mail Squirrel-Resistant Bird Feeder. Novelty envelope shape bird feeder with AIR MAIL imprint! ![]() Killing bred reaper ark9/6/2023 ![]() ![]() I used to farm death worms on scorched the same way. Reapers are incredibly tanky without a light on it, so yes it could very well take on a alpha rex or any alphas for that matter without losing a quarter of its health. I have over 20+ reapers to this day, and I can assure you that there is no other mount id rather have. Reapers are an incredibly impressive mount to have on the ark and can make your life a lot easier on the arks you may live on. Getting around easier is great on a King, they are tough, and they fight well. ![]() King has a bite, can jump, turns quicker, and has 2 additional tail-attacks: A spin-move that knocks things back quite far, and a projectile that slows and can ground fliers. Rex has a bite, saddle, and the poop-roar (fun for PvP but otherwise useless). Stacking that with imprint you have a good deal of damage reduction with no saddle. When the light is turned off, they take 90% reduced damage. The King has a great deal of usefulness due to its maneuverability and extra attacks.Also, when under the effect of a light-pet Reaper Kings and Queens take full damage. Resistance/Extras: It is worth noting that the Rex can achieve more damage reduction than the King can because of imprint AND saddle (if you are above approximately a 90-armor saddle on the Rex). Due to breeding/mutations the Rex can achieve more damage than the -AVERAGE- King can, since Rexs are regularly higher than 600% at post-imprint levels if you buy someones crap off the forums. 8% difference, negligible), so they are essentially the same dps. ![]() The Rex and the King at nearly 600% melee damage are less than 1% different in DPS (6625 VS 6678, difference being 53 so about. Training dummies are made of thatch, so damage numbers are way skewed and higher than if you were fighting a dinosaur but are good for testing purposes. I imprinted it fully, matured it immediately, and put a 101 armor saddle on it. I spawned in a male and female Rex, amped up breeding, and hatched the egg. To test their actual output, I loaded singleplayer and moved a fully imprinted King to SE from Abb. Will most likely use it for meat runs and such lol. You think a reaper is any better than a rex, or is it between the spino and rex in terms of usefulness? And flawlessly take down an alpha rex on one? They look cool but ive heard their melee isn't too amazing.ĭamage: Rex base dmg is 62, Reaper King base dmg is 75, and the Rex attacks faster than the King does (Rex attacks approximately once every 4/5 of a second, the King attacks exactly 1 time a second). I play pve, was wondering if Reaper Kings are worth owning. In both cases, they eat a lot of meat throughout their growth processes. ![]() not to mention at baby, they can't hear or see, only smell, and thus will always wander until they are juveniles. They lose hunger if they attack, which is something that needs to take note of since they may refuse to eat. They are easy and yet tedious for first timers to raise. Drakes can also sense its presence, but unlike direwolf, can't exactly tell where, only know its around.) (Only the tribe can see the mound of dirt unless you have a dire wolf to sniff it out. But their sheer tail size are more annoying than Rex, which means you need to either find an isolated zone for reaper king to stay there without movement hinderance or tell it to bury itself. Reaper King has many uses, including grounding a flying dino, sweeping away at most dino if surrounded, and hell, even jump like Procoptodon and Karkinos, whereas Rex can just climb up and roar to make most weak dino and players poop, stopping whatever the dino was doing earlier. Rex on the other hand, can breed, and their offspring can mutate, possibly up to a max of 6 stat mutation and other colors.The only way you can get an "out of natural color" color is through events, and even then, its a gamble for Reaper King if you wanna do that way since Queens only has coded color region they do not have an active color region on themselves. Reaper King can't breed, and thus can never get any better mutation than what the queen usually have based on the embryo you are impregnated by, including "level efficiency" (+74 max). (If anyone can link the thread it would be great) Someone had posted comparison in between Reaper King and Rex in another thread, but I am having a hard time trying to find it. ![]() New manager tips for first day9/6/2023 ![]() ![]() Here are some guidelines for how and when to ask: But in your first week, you want to find the right time to ask questions. By asking your leaders and peers for new information, you’ll get up to speed quickly. Related: Become a Networking Expert in 7 StepsĪs a new employee, you are likely to do your job better if you know what to do. If you forget someone’s name, honesty is the best policy: “ I’m sorry, I’ve been taking in a lot of new information over the last few days. Don’t get overwhelmed by needing to remember everyone’s name, though. You can do this by saying the person’s name back to them and writing down a quick note about them when you part. You can make a great first impression by making someone else feel heard.ĭo your best to remember names. If they seem receptive, you may want to get to know this person better. As you’re introducing yourself, take note of how the other person is reacting. Don’t interrupt a meeting to introduce yourself or speak too loudly in communal spaces. Pay attention to your surroundings and other people. Prepare your opening lines ahead of time so you have a script at the ready when you encounter a new face. Here are some ways to ease into your introductions: In meetings, you could ask the organizer to give you some time at the beginning or end to introduce yourself. Mention to your manager that introducing yourself is a priority for you and ask for a list of people you should get to know. If meeting new people is particularly important to you, you can enlist the help of others. So, find the timing that feels right and give a quick, energetic introduction to the people you don’t know yet. But in the first days of a new job, you want your enthusiasm to shine through. It’s a natural feeling-when you’re new, you don’t necessarily want to call attention to yourself. Studies have shown that anxiety in new situations can come in part from not feeling confident in how to introduce ourselves. The goal is to learn about your new workplace and feel out your place in that ecosystem. You want to make a great first impression, but you shouldn’t put too much pressure on yourself to get everything right. Success during week one is about balance. ![]() Create a Resume The first week of a new job ![]() Freedom statue capitol9/6/2023 ![]() The plaster model of Freedom is on display in the U.S. The government agreed to rent his foundry, pay him $400 a month, and cover costs of material and labor. Mills would be happy he had Reid with him for his next commission - casting Thomas Crawford’s statue of Freedom to sit atop the still-unfinished Capitol dome. He bought him because of his evident talent for the business … aged 42 years, mulatto color, short in stature, in good health, not prepossessing in appearance, but smart in mind, a good workman in a foundry.” many years ago, when he was quite a youth. ![]() In 1862 Mills filed government papers that referred to Reid, whom “he purchased in Charleston, S.C. Architect of the Capitolįortunately, Mills had some highly skilled workers, including one enslaved man, named in the records as Philip Reid. Clark Mills standing in front of his foundry, circa 1862. The bronze casting process is difficult and exacting and requires great patience and skill. It too was a success, and was placed in Washington Circle in the West End.Ī hulking octagonal building, the Bladensburg Road foundry could be a hot, dirty place to work. There he produced another equestrian statue, this time of George Washington. Following that success, Mills built a foundry just off Bladensburg Road in the present day Langdon neighborhood. It was also the first equestrian statue to be balanced solely on the horse’s hind legs. Mills unveiled it in 1853 to great acclaim. ![]() For that, a temporary foundry was set up near the White House and there Mills and his workers produced one of the first bronze statues ever cast in this country. Mills moved here from South Carolina in the 1840s when he won a competition for an equestrian statue of Andrew Jackson to be placed in Lafayette Park. ![]() Highsmith collectionĭid you know that great, monumental art was once produced in our neck of the woods? A little over a mile away from Brookland, just past the site of Queen’s Chapel, sculptor Clark Mills once had his foundry. ![]() Dato dxd9/6/2023 ![]() Research indicates that high TROP2 expression is associated with cancer cell growth and proliferation and poor patient survival. , High TROP2 expression also has been identified in a majority of NSCLCs. TROP2 (trophoblast cell-surface antigen 2) is a transmembrane glycoprotein that is overexpressed in many cancers including up to 80 percent of patients with triple negative breast cancer. The collaboration is expected to enhance the corporate and shareholder value for Daiichi Sankyo over the mid- to long-term. Impact on Daiichi Sankyo’s consolidated financials for fiscal year ending Mawill be announced at an appropriate time in the future. The upfront payment and regulatory milestones will be booked as revenue over the period in which Daiichi Sankyo has contractual performance obligations under this collaboration. AstraZeneca is expected to book sales in other markets worldwide, including China, Australia, Canada and Russia. Daiichi Sankyo is expected to book sales in U.S., certain countries in Europe, and certain other markets where Daiichi Sankyo has affiliates. Total payments under the agreement have the potential to reach up to $6 billion.ĭaiichi Sankyo and AstraZeneca will share equally development and commercialization costs as well as profits from DS-1062 worldwide, except for Japan. Contingent payments of up to $5 billion include $1 billion for achievement of future regulatory milestones, and $4 billion for sales-related milestones. Under the terms of the agreement, AstraZeneca will pay Daiichi Sankyo an upfront payment of $1 billion, of which $350 million is due upon execution, $325 million after 12 months and $325 million after 24 months. We now have six potential blockbusters in oncology with more to come in our early and late pipelines.” “We are delighted to enter this new collaboration with Daiichi Sankyo and to build on the successful launch of ENHERTU to further expand our pipeline and leadership in oncology. “We see significant potential in this antibody drug conjugate in lung as well as in breast and other cancers that commonly express TROP2,” said Pascal Soriot, Chief Executive Officer, AstraZeneca. As we have done with ENHERTU, we will jointly design and implement strategies to maximize the value of DS-1062.” ![]() “This new strategic collaboration with AstraZeneca, a company with extensive experience and significant expertise in the global oncology business, will enable us to deliver DS-1062 to more patients around the world as quickly as possible. “DS-1062, one of our lead DXd ADCs that will form a pillar of our next mid-term business plan, has the potential to become a best-in-class TROP2 ADC in multiple tumors, including lung and breast cancers,” said Sunao Manabe, Representative Director, President and CEO of Daiichi Sankyo Company, Limited. This agreement represents the second global ADC collaboration between the two companies following a similar agreement in March 2019 for Daiichi Sankyo’s ENHERTU®, a HER2 directed DXd ADC. ![]() Daiichi Sankyo will manufacture and supply DS-1062. Tokyo, Munich and Basking Ridge, NJ – (July 27, 2020) – Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) announced today that it has entered into a global development and commercialization agreement with AstraZeneca (LSE, STO, NYSE: AZN) for Daiichi Sankyo’s DS-1062, a TROP2 directed DXd antibody drug conjugate (ADC), currently in phase 1 clinical development for non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC).ĭaiichi Sankyo and AstraZeneca will jointly develop and commercialize DS-1062 worldwide, except in Japan where Daiichi Sankyo will maintain exclusive rights.
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